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Updated: Aug 19, 2026
Non-invasive Imaging of Leukocyte Homing and Migration in vivo
Published on: December 5, 2010
The effect of radiographic contrast media on leukocyte motility
C A Roobottom1, R Farrow, I P Wells
1Department of Radiodiagnosis, Plymouth Post Graduate Medical School, England.
Rationale And Objectives:
Studies describing the effects of radiographic contrast media (RCM) in leukocyte chemotaxis have been contradictory. No studies have been performed after in-vivo exposure. The authors assess the effect of RCM on leukocytes following in-vivo exposure.
Methods:
Seventeen patients were studied after intraarterial bolus injection of 75 mL of iohexol (300 mg/mL) or iotrolan (300 mg/mL), 30 minutes and 24 hours postinjection; chemotaxis was assessed using an ex-vivo whole-blood under-agarose method.
Results:
With iohexol, there was a profound reduction in chemotaxis compared with the preinjection state (P = .001) at 30 minutes. No effect, however, was seen at 24 hours. With iotrolan, no significant reduction in chemotaxis was seen at 30 minutes or at 24 hours.
Conclusions:
Radiographic contrast media have differing effects on leukocyte chemotaxis. This may be of significance in the selection of appropriate RCM in certain patients.
