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A controlled family study in panic disorder

W Maier1, D Lichtermann, J Minges

  • 1Department of Psychiatry, University of Mainz, Germany.

Journal of Psychiatric Research
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Panic disorder shows a significant familial risk, with a 7.9% age-corrected risk in relatives of affected individuals compared to 2.3% in controls. This suggests overlapping etiological factors with depression and alcoholism.

Area of Science:

  • Psychiatry
  • Genetics
  • Epidemiology

Background:

  • Panic disorder (PD) is known to be familial, but studies vary on risk figures.
  • The influence of comorbidity and relative's gender on PD inheritance is unclear.
  • Family studies controlling for proband comorbidity are needed.

Purpose of the Study:

  • To determine the morbid risks of panic disorder in first-degree relatives of "pure" PD probands.
  • To investigate the familial risk of major depression and alcoholism in PD families.
  • To explore the segregation of agoraphobia within families.

Main Methods:

  • Compared morbid risks in families of 40 "pure" PD probands (DSM-III-R) with 80 general population controls.
  • Probands were free of psychotic disorders, major depression, or alcoholism.

Related Experiment Videos

  • First-degree relatives were assessed for panic disorder, agoraphobia, major depression, and alcoholism.

    • Main Results:

    • The age-corrected morbid risk for panic disorder was 7.9% in relatives of PD probands versus 2.3% in controls.
    • Agoraphobia predominantly occurred in female relatives of agoraphobic probands.
    • Increased familial risks for major depression and alcoholism were observed.

    Conclusions:

    • Panic disorder has a significant familial component.
    • Overlapping etiological factors may exist between panic disorder, major depression, and alcoholism.
    • Family studies excluding comorbidity are crucial for understanding PD's genetic basis.