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Related Experiment Videos

Antibiotic release from impregnated pellets and beads

G W Bowyer1, N Cumberland

  • 1Queen Elizabeth Military Hospital, Woolwich, London.

The Journal of Trauma
|March 1, 1994
PubMed
Summary

Plaster of Paris (PoP) pellets offer superior antibiotic release for open fracture wound treatment compared to polymethylmethacrylate (PMMA) beads. PoP is ideal for short-term infection prophylaxis.

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Area of Science:

  • Orthopedic Surgery
  • Infectious Disease
  • Materials Science

Background:

  • Antibiotic-impregnated beads are increasingly used for initial open fracture wound treatment.
  • These beads provide high local antibiotic concentrations in the initial days post-injury.

Purpose of the Study:

  • To evaluate antibiotic elution from pellets made of polymethylmethacrylate (PMMA) or plaster of Paris (PoP).
  • To compare the release profiles of various antibiotics from these carrier materials.

Main Methods:

  • Antibiotics (benzylpenicillin, flucloxacillin, amoxycillin, Co-Amoxiclav, ciprofloxacin, imipenem, gentamicin) were incorporated into PMMA or PoP pellets.
  • In vitro antibiotic elution over 72 hours was quantified using agar-diffusion microbiologic assays.

Main Results:

  • An initial rapid antibiotic release phase occurred within 12-24 hours.
  • PoP pellets demonstrated at least a four-fold greater release than PMMA pellets.
  • A sustained, gradually diminishing elution phase followed the initial burst release.

Conclusions:

  • PoP pellets exhibit favorable antibiotic release compared to current PMMA beads.
  • PoP pellets are particularly suitable for short-term applications, such as infection prophylaxis in open fractures.

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