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Updated: Jul 31, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
[Changes of the renin-angiotensin-aldosterone system and immunologic parameters in essential and symptomatic arterial
Insights
Hormonal and immune changes in hypertension are not linked to specific kidney diseases. These shifts play a key role in maintaining and progressing high blood pressure.
Area of Science:
- Nephrology
- Endocrinology
- Immunology
Abstract:
The authors examined 150 patients with pronounced arterial hypertension: 73 with essential hypertension, 42 with chronic glomerulonephritis, 26 with chronic pyelonephritis and 10 with diabetic glomerulosclerosis. In addition to conventional tests, measurements were made of renin activity, levels of plasma aldosterone and hydrocortisone, IgA, IgG, IgM, CIC. A significant rise in concentrations of aldosterone, hydrocortisone against a significant fall in those of plasma renin were registered in all the patients irrespective of the disease. Significant differences between the groups by the renin profile, aldosterone and hydrocortisone levels were absent. It is suggested that changes in the hormonal spectrum and immunological indices are independent of renal affections in hypertension, while involvement of renin-angiotensin-aldosterone system in hypertension stabilization has no nosological specificity. The pattern of the immunity shifts evidences for their important pathogenetic role in maintenance and progression of arterial hypertension.
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