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Two new antiinflammatory elemanolides from Centaurea chilensis
R E Negrete1, N Backhouse, I Cajigal
1Pharmacognosy Laboratory, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago.
Journal of Ethnopharmacology
|December 1, 1993
Abstract:
Two previously undescribed elemanolide esters, the 2-methylpropanoate and 2-methyl-2-propenoate of 11,13-dehydromelitensin, were isolated in the course of a bioassay-guided fractionation from the aerial parts of Centaurea chilensis Hook. et Arn., used traditionally to treat 'gout and rheumatism'. The mixture of both substances exhibits anti-inflammatory activity in the carrageenan-induced paw edema assay.