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Dengue: the risk to developed and developing countries

T P Monath1

  • 1Research and Medical Affairs, OraVax, Inc., Cambridge, MA 02139.

Proceedings of the National Academy of Sciences of the United States of America
|March 29, 1994
PubMed
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Dengue fever epidemics are rising globally due to increased exposure to the Aedes aegypti mosquito, driven by human behavior. Sequential infections increase the risk of severe dengue hemorrhagic fever (DHF).

Area of Science:

  • Medical Entomology
  • Virology
  • Epidemiology

Background:

  • Dengue viruses (Flaviviridae family) are transmitted by Aedes mosquitoes, primarily affecting humans.
  • Dengue fever epidemics have surged globally in the past two decades, with hyperendemic transmission expanding geographically.
  • Dengue hemorrhagic fever (DHF), a severe form, is linked to sequential dengue virus infections and is increasingly prevalent.

Purpose of the Study:

  • To analyze the factors contributing to the emergence of dengue as a major global health concern.
  • To investigate the role of human demography, behavior, and mosquito vector populations in dengue's spread.
  • To explore virus-specific factors influencing dengue epidemiology and potential future trends.

Main Methods:

  • Review of epidemiological data on dengue incidence and geographic spread.

Related Experiment Videos

  • Analysis of demographic and behavioral changes impacting Aedes aegypti populations.
  • Examination of virological factors associated with dengue pathogenesis and transmission.

    • Main Results:

    • Increased human populations and altered behaviors have led to larger Aedes aegypti populations and greater human exposure.
    • Sequential dengue virus infections significantly elevate the risk of developing DHF.
    • Dengue's epidemiological landscape has dramatically shifted, particularly in Asia and the Americas.

    Conclusions:

    • Human demographic and behavioral changes are primary drivers of the dengue epidemic.
    • Understanding virus-specific factors is crucial for predicting future dengue evolution and spread.
    • Effective vector control strategies and public health interventions are essential to mitigate the growing dengue burden.