Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Nephroblastoma (Wilms' tumor)]

J Lemerle1, M F Tournade

  • 1Institut Gustave-Roussy, service de pédiatrie, Villejuif.

La Revue Du Praticien
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Nephroblastoma, a common childhood cancer, has seen its cure rate soar to 90% due to chemotherapy advances. Research now focuses on genetic links, like chromosome 11 deletion, and improved treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Treatment of childhood cancer in Africa. Action of the Franco-African childhood cancer group].

Medecine tropicale : revue du Corps de sante colonial·2008
Same author

[The French-African paediatric oncology group: a first stage report].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2005
Same author

[Treatment of childhood cancer in Africa. Preliminary results of the French-African paediatric oncology group].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2005
Same author

[Antibioprophylaxy in hand surgery: toward a professional consensus].

Chirurgie de la main·2004
Same author

Reduction of postoperative chemotherapy in children with stage I intermediate-risk and anaplastic Wilms' tumour (SIOP 93-01 trial): a randomised controlled trial.

Lancet (London, England)·2004
Same author

[Management of cancer in children in Africa].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2003

Area of Science:

  • Pediatric Oncology
  • Medical Genetics

Context:

  • Nephroblastoma is a frequent pediatric tumor with significant treatment advancements.
  • Improved diagnostic methods including radiology and ultrasonography have become standard.
  • Understanding the genetic basis of nephroblastoma is a key research focus.

Purpose:

  • To summarize the current understanding and treatment of nephroblastoma.
  • To highlight the impact of chemotherapy on nephroblastoma cure rates.
  • To discuss the association between nephroblastoma and congenital/chromosomal anomalies.

Summary:

  • Nephroblastoma treatment has dramatically improved, with cure rates rising from 50% to 90% over 20 years, largely due to chemotherapy.
  • Diagnosis is facilitated by advanced imaging and well-established histological features.

Related Experiment Videos

  • Current research investigates links between nephroblastoma development, congenital malformations, and chromosomal anomalies, particularly deletion of chromosome 11 short-arm.
  • Treatment involves nephrectomy and chemotherapy, with preoperative chemotherapy enhancing outcomes. Radiotherapy use is minimized due to potential sequelae.

    • Impact:

    • Advances in chemotherapy have significantly increased nephroblastoma survival rates in children.
    • Understanding genetic predispositions like chromosome 11 deletion may lead to targeted therapies.
    • Multimodal treatment strategies, including surgery and chemotherapy, offer the best prognosis for pediatric nephroblastoma patients.