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Ascorbic acid is an abettor in calcium urolithiasis: an experimental study

P P Singh¹, R Kiran, A K Pendse

¹Department of Biochemistry, R.N.T. Medical College, Udaipur, Rajasthan, India.

Scanning Microscopy

|September 1, 1993

Summary

Ascorbic acid supplementation did not cause urolith formation in guinea pigs. However, it worsened calcification in animals with hypercalciuria or hyperoxalururia.

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Area of Science:

Biochemistry
Nephrology
Nutritional Science

Background:

Ascorbic acid (vitamin C) is widely supplemented.
Its role in urolithiasis is debated.
Previous studies suggest high doses do not cause stone formation.

Purpose of the Study:

To evaluate ascorbic acid's effect on the lithogenic process in guinea pigs.
To determine if ascorbic acid exacerbates stone formation under specific conditions.

Main Methods:

Two sets of guinea pig experiments were conducted.
Animals received varying doses of ascorbic acid (10-60 mg/100g/day) for 105 days.
Second experiment involved hypercalciuric and hyperoxaluric models over 45 days.

Main Results:

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Ascorbic acid supplementation did not induce crystalluria, calcification, or stone formation at tested doses.
In hypercalciuric and hyperoxaluric models, ascorbic acid exacerbated renal and bladder calcification.

Conclusions:

Ascorbic acid, within the tested dosage range, does not appear to cause urolith formation.
However, it may worsen existing calcification processes in susceptible individuals.