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Tumour imaging with radiolabelled monoclonal antibodies
Abstract:
The specificity of nuclear medicine techniques for imaging cancer is improved by characterization of the cancer cell as different from the normal. Radioimmunoscintigraphy, imaging with radiolabelled antibodies and radioimmunotherapy, using beta emitting radionuclides, are developing to give specific cancer identification and treatment. The new approaches include genetic engineering of humanized antibody constructs for imaging and bifunctional antibody like molecules for a two stage approach to radioimmunotherapy. There is an important clinical role for current radioimmunoscintigraphy with 99Tcm Technetium as the signal.
Insights
Nuclear medicine advances cancer imaging and treatment using radiolabeled antibodies. Radioimmunoscintigraphy with technetium-99m offers current clinical value for cancer detection.
Area of Science:
- Oncology
- Nuclear Medicine
- Immunology
Background:
- Cancer cell characterization enhances nuclear medicine imaging specificity.
- Radioimmunoscintigraphy and radioimmunotherapy are emerging cancer detection and treatment modalities.
- Antibody-based approaches offer targeted cancer imaging and therapy.