[Stimulation of secondary immune response to antigen D from the Rh system]

The authors report the results of investigations on stimulation of secondary immunological response in 30 subjects immunized with antigen D for obtaining highly active sera for production of anti-D immunoglobulin. The analysis of these results showed that application of frequent antigenic stimuli leads to a short-term rise in the antibody level but in 10 cases no expected effect was obtained. None of the immunized subjects produced serologically detectable antibodies reacting with platelets.