Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimization of myocardial function

N R Alpert1, L A Mulieri, G Hasenfuss

  • 1University of Vermont, Department of Physiology and Biophysics, Burlington.

Basic Research in Cardiology
|January 1, 1993
PubMed
Summary

The heart muscle adapts to increased metabolic demands using strategies similar to those seen across different muscle types and species. These adaptations involve adjustments in the cross-bridge cycle and excitation-contraction coupling for both short-term and long-term changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Precision medicine enhances personalized medicine in cardiology].

Innere Medizin (Heidelberg, Germany)·2024
Same author

[Cardiac amyloidosis].

Innere Medizin (Heidelberg, Germany)·2023
Same author

Intrarenal Doppler ultrasonography in patients with HFrEF and acute decompensated heart failure undergoing recompensation.

Clinical research in cardiology : official journal of the German Cardiac Society·2023
Same author

Resting and exercise haemodynamic characteristics of patients with advanced heart failure and preserved ejection fraction.

ESC heart failure·2021
Same author

[Less is more in cardiology and angiology].

Der Internist·2021
Same author

[Primary care medicine-Part II : Practice-oriented diagnosis and treatment pathways].

Der Internist·2021

Area of Science:

  • Physiology
  • Muscle Biology
  • Cardiac Function

Background:

  • Cardiac output must meet varying metabolic needs, from rest to intense exercise.
  • The heart employs adaptive strategies for short- and long-term demand changes.
  • These strategies are comparable to mechanisms differentiating muscle types and species.

Purpose of the Study:

  • To review the heart's utilization of adaptive strategies for meeting diverse physiological demands.
  • To compare cardiac adaptations with inter-species and intra-species muscle performance differences.
  • To elucidate the roles of the cross-bridge cycle and excitation-contraction coupling in cardiac adaptation.

Main Methods:

  • Comparative analysis of muscle types (tortoise, rat soleus, rat EDL) based on contractile properties and myosin ATPase activity.

Related Experiment Videos

  • Examination of cardiac muscle responses to short-term demand changes (catecholamines).
  • Investigation of cardiac adaptations to long-term demand changes (myocardial hypertrophy via hyperthyroidism and pressure overload).

    • Main Results:

    • Fast muscles (e.g., FM, REDL) exhibit high power and low economy, linked to myosin cross-bridge kinetics and excitation-contraction coupling.
    • Catecholamine stimulation increases cardiac power but decreases economy, affecting cross-bridge and excitation-contraction systems.
    • Myocardial hypertrophy due to hyperthyroidism increases power and decreases economy; pressure overload shows opposite changes, mediated by contractile and excitation-contraction systems.

    Conclusions:

    • Cardiac muscle employs strategies similar to other muscle types to meet changing metabolic demands.
    • The cross-bridge cycle and excitation-contraction coupling are key regulators of cardiac performance under varying loads.
    • Understanding these adaptive mechanisms is crucial for comprehending cardiac physiology and pathology.