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Taurine and myocardial noradrenaline
R Chahine1, J Hanna, K Abou Khalil
1Centre de Recherche, Hôpital du Sacré-Coeur, Montréal, Canada.
Arzneimittel-Forschung
|February 1, 1994
Summary
Taurine, an anticonvulsant, may reduce peripheral sympathetic activity. It enhances noradrenaline breakdown and decreases its release, potentially by regulating intracellular calcium ions.
Area of Science:
- Pharmacology
- Neuroscience
- Cardiovascular Research
Background:
- Taurine is recognized for its anticonvulsant properties.
- It is also utilized as a supplementary treatment for cardiovascular conditions.
- Its precise impact on cardiovascular neurotransmission requires further elucidation.
Purpose of the Study:
- To investigate the effects of taurine on noradrenergic transmission in the isolated rabbit heart.
- To determine taurine's influence on noradrenaline uptake, release, and catabolism.
Main Methods:
- Utilized an isolated rabbit heart model.
- Pre-labeled the heart tissue with 3H-noradrenaline.
- Administered taurine at concentrations of 1 and 10 mmol/l.
- Assessed noradrenaline uptake, spontaneous and induced release, and catabolism.
Main Results:
- Taurine did not affect neuronal or extraneuronal noradrenaline uptake.
- At 10 mmol/l, taurine reduced spontaneous noradrenaline release and enhanced its catabolism.
- Taurine diminished noradrenaline release induced by dimethylphenylpiperazinium and nerve stimulation, but not by tyramine.
Conclusions:
- Taurine may attenuate peripheral sympathetic activity.
- This effect is likely mediated by accelerated noradrenaline catabolism and reduced release.
- Taurine's mechanism may involve the prevention of intracellular calcium ion level increases.