[Leukemia and nuclear proteins]

Recently, lot of evidences are showing that the expression of some subsets of genes are essential for leukemogenesis. It becomes clear that nuclear proteins-namely transcription factors-have important roles for the development of leukemias from the studies of avian virus-induced leukemia, murine leukemia models of transgenic mice, and chromosome translocations of human leukemias. In this review article, some transcription factors involved in leukemogenesis are chosen and their roles in leukemogenesis are explained.