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[Inner-ear of monkeys under the influence of streptomycin-sulfate (author's transl)]
Abstract:
Eight monkeys were treated with 65 X 150 mg/kg Streptomycine-Sulfate per day given intramuscularly. Their vestibular reactions were investigated several times during and after (up to 7 1/2 months) the medication. Using nystagmography, a decrease of excitability could be realized as long as the drug was given. After the stop of the injections the excitability returned, mostly even up to the normal level. The most reliable vestibular reactions were the vestibular threshold, respectively duration and frequency of the postrotatory nystagmus. Additional medicaiton of Ozothin had some influence on the toxicity of Streptomycine towards the auditory system, but no effect at all regarding the vestibular reactions.
Insights
This study investigated Streptomycin-Sulfate's effects on monkey vestibular reactions. While the drug temporarily decreased vestibular excitability, it mostly returned to normal levels after treatment cessation.
Area of Science:
- Neuroscience
- Pharmacology
- Ototoxicology
Background:
- Streptomycin-Sulfate is an antibiotic known for potential ototoxicity.
- Vestibular function is crucial for balance and spatial orientation.
Purpose of the Study:
- To assess the impact of Streptomycin-Sulfate on vestibular reactions in monkeys.
- To determine the reversibility of these effects after drug discontinuation.
Main Methods:
- Eight monkeys received intramuscular Streptomycin-Sulfate (150 mg/kg/day) for an unspecified duration.
- Vestibular reactions were monitored using nystagmography during and up to 7.5 months post-treatment.
- Key metrics included vestibular threshold, duration, and frequency of postrotatory nystagmus.
Main Results:
- A decrease in vestibular excitability was observed during Streptomycin-Sulfate administration.
- Vestibular function largely recovered to normal levels after treatment cessation.
- Ozothin co-administration showed no effect on vestibular reactions but influenced auditory toxicity.
Conclusions:
- Streptomycin-Sulfate induces temporary vestibular hyperexcitability in monkeys.
- Vestibular function demonstrates significant recovery potential post-treatment.
- Ozothin does not mitigate Streptomycin-Sulfate's vestibular effects.