Gelsolin is localized in neuronal growth cones
Related Experiment Video
Updated: Nov 9, 2026

Analyses of Actin Dynamics, Clutch Coupling and Traction Force for Growth Cone Advance
Published on: October 21, 2021
1Department of Neurochemistry and Neuropharmacology, Osaka University Medical School, Japan.
Abstract:
Gelsolin, a Ca(2+)-sensitive actin filament-severing protein, is involved in actin turnover. Immunocytochemical study with anti-gelsolin antibody revealed that the protein is localized in both filopodia and the body part of growth cones of differentiated PC12 cells with nerve growth factor (NGF) and of rat dorsal root ganglion neurons. Here, we identified gelsolin as one of the molecular bases for the Ca(2+)-dependent movement of growth cones.
Related Concept Videos
Actin Filament Depolymerization
In F-actin, the ADF/cofilin proteins...
Activation and Inactivation of G Proteins
Coat Assembly and GTPases
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...

