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Related Experiment Videos

New perspectives in allergic asthma

S O Freedman

    Canadian Medical Association Journal
    |February 21, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Recent advances in allergic asthma diagnosis and treatment include the radioallergosorbent test (RAST) for lgE antibodies and new inhaled medications. These treatments offer effective relief with fewer side effects than traditional methods.

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    Area of Science:

    • Allergy and Immunology
    • Pulmonology
    • Pharmacology

    Background:

    • Allergic asthma diagnosis and treatment have seen significant recent advancements.
    • Traditional allergy testing methods like skin tests have drawbacks including patient discomfort and risk.

    Purpose of the Study:

    • To review recent progress in allergic asthma diagnosis and treatment.
    • To highlight the benefits of new diagnostic and therapeutic approaches.

    Main Methods:

    • Evaluation of the radioallergosorbent test (RAST) for measuring allergen-specific lgE antibodies in vitro.
    • Review of new inhaled anti-asthmatic drugs, including disodium cromoglycate and beclomethasone dipropionate.

    Main Results:

    • The RAST provides results comparable to skin tests but is more convenient and safer for patients.

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  • New inhaled drugs like disodium cromoglycate and beclomethasone dipropionate are effective with minimal systemic side effects.
  • Disodium cromoglycate can reduce exercise- or antigen-induced bronchospasm and may allow for corticosteroid reduction.
  • Beclomethasone dipropionate allows for significant reduction or withdrawal of systemic corticosteroid therapy, though adrenal function recovery may be delayed.

    • Conclusions:

    • Modern diagnostic tools like RAST improve allergic asthma management.
    • New inhaled therapies offer effective and safer treatment options for allergic asthma.
    • Careful management, including overlapping drug regimens, is necessary when reducing systemic corticosteroids.