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Activin-mediated mesoderm induction requires FGF

R A Cornell1, D Kimelman

  • 1Department of Biochemistry SJ-70, School of Medicine, University of Washington, Seattle 98195.

Development (Cambridge, England)
|February 1, 1994
PubMed
Summary
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Fibroblast growth factor (FGF) signaling is essential for full mesoderm induction by activin in Xenopus embryos. Activin

Area of Science:

  • Developmental biology
  • Molecular biology
  • Embryology

Background:

  • Early mesoderm patterning in Xenopus embryos relies on intercellular signals.
  • Fibroblast growth factor (FGF) and TGF-beta families are key mesoderm inducers.
  • Activin is more potent than FGF in inducing dorsal and anterior mesoderm.

Purpose of the Study:

  • To investigate the role of FGF signaling in activin-induced mesoderm formation.
  • To determine if FGF is required for the full induction of mesoderm by activin.

Main Methods:

  • Utilized a dominant-negative form of the Xenopus type 1 FGF receptor.
  • Cultured animal hemisphere explants (animal caps) with activin.
  • Assessed gene induction (cardiac actin, Xbra, gsc, Xlim-1) in response to treatments.

Related Experiment Videos

Main Results:

  • FGF signaling is necessary for complete mesoderm induction by activin.
  • Animal caps with truncated FGF receptor showed reduced gene induction (cardiac actin, Xbra).
  • Head organizer-specific genes (gsc, Xlim-1) were less sensitive to FGF signaling levels.

Conclusions:

  • Activin-mediated mesoderm induction in Xenopus is dependent on FGF signaling.
  • Different mesodermal genes exhibit varying sensitivities to FGF signaling levels.
  • Findings align with the observed phenotype in truncated FGF receptor-injected embryos.