Related Experiment Video
Updated: Sep 15, 2026

Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells
Published on: July 18, 2019
Androgenic modulation of lipid metabolism at subcellular sites in cholestatic rats
1Department of Physiology, Louisiana State University Medical Center, New Orleans.
Abstract:
The present studies examine the modulation of lipid metabolism at subcellular sites in the liver of control and cholestatic rats by a male sex hormone. Subcutaneous injection of testosterone enanthate (5 mg/kg body weight), increased triacylglycerol lipase (TG-lipase) and neutral cholesterol ester hydrolase (CE-hydrolase) activity in endosomes of normal rats. During induced cholestasis, TG-lipase and CE-hydrolase activity in endosomal fractions were decreased compared to those in endosomes of age-matched sham-operated female controls. Following testosterone administration to cholestatic rats, endosomal lipolytic enzyme activity increased to approximate the levels of normal controls. These observations may provide insight into the alterations in lipid metabolism which accompany cholestatic liver disease.
Related Concept Videos
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Cholesterol: Significance and Regulation
Considering cholesterol and...

