Related Experiment Videos
[Pleural malignant mesothelioma complicated with disseminated intravascular coagulation]
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|December 1, 1993
Abstract:
Three cases of MPM complicated with DIC were reported in a total of 6862 autopsies (0.04%) from 1950 to 1989 year in our university hospital. All the three cases showed hemorrhagic patches, shock, decreased platelets and fibrinogen, and prolonged prothrombin and thrombin time. Hyaline thrombosis was observed in the pulmonary interstitial microvessels. We have also discussed the diagnosis and pathogenesis of DIC.
Insights
Malignant pleural mesothelioma (MPM) rarely complicates with disseminated intravascular coagulation (DIC), occurring in 0.04% of autopsies. This study details three such cases, highlighting key clinical and pathological features of DIC in MPM patients.
Area of Science:
- Pathology
- Oncology
- Hematology
Background:
- Malignant pleural mesothelioma (MPM) is a rare asbestos-related cancer.
- Disseminated intravascular coagulation (DIC) is a complex hematological disorder with high mortality.
- The co-occurrence of MPM and DIC is exceptionally infrequent.
Observation:
- A retrospective analysis of 6862 autopsies (1950-1989) identified three cases of MPM with DIC.
- Clinical presentation included hemorrhagic patches and shock.
- Laboratory findings revealed decreased platelets and fibrinogen, with prolonged prothrombin and thrombin times.
Findings:
- Pathological examination showed hyaline thrombosis in pulmonary interstitial microvessels.
- DIC in MPM cases presented with characteristic consumptive coagulopathy.
- The study confirms a low incidence of DIC complicating MPM.
Implications:
- Understanding the pathogenesis of DIC in MPM is crucial for timely diagnosis and management.
- Early recognition of DIC signs in MPM patients may improve outcomes.
- Further research into the mechanisms linking MPM and DIC is warranted.