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Infections associated with implanted blood pumps

G L Burns1

  • 1Institute for Biomedical Engineering, University of Utah, Salt Lake City.

The International Journal of Artificial Organs
|November 1, 1993
PubMed
Summary

The Jarvik-7 total artificial heart (TAH) has supported many patients, with most receiving transplants. While complications like hemorrhage and infection occur, TAH infection rates have significantly decreased.

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Medical device associated infections.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2000

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Medical Devices

Background:

  • Prosthetic blood pumps, including total artificial hearts (TAH), are crucial for mechanical circulatory support.
  • The Jarvik-7 and Jarvik 7-70 (Symbion-7 and Symbion 7-70) TAH have been utilized globally in experimental and clinical settings.

Purpose of the Study:

  • To review the clinical use and outcomes of the Jarvik-7 and Jarvik 7-70 total artificial hearts.
  • To identify common complications and pathogens associated with TAH implantation.

Main Methods:

  • Review of clinical data from 190 patients implanted with Jarvik-7/7-70 TAH.
  • Analysis of patient outcomes, including cardiac transplantation rates and survival.
  • Identification and analysis of reported complications and causative pathogens.

Main Results:

  • 133 out of 190 patients received cardiac transplants, with 68 survivors post-transplant.
  • Primary complications included postoperative hemorrhage, thrombosis with thromboembolism, and infection.
  • The incidence of TAH-related infection has decreased significantly, now around 30%.

Conclusions:

  • The Jarvik-7 TAH has been instrumental in supporting patients awaiting or ineligible for cardiac transplantation.
  • While complications persist, ongoing improvements have led to a notable reduction in infection rates.
  • Staphylococcus epidermidis and Pseudomonas aeruginosa remain the predominant pathogens associated with TAH infections.

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