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In-vitro antibacterial activity of cefepime: a multicentre study
J Duval1, C J Soussy, J F Acar
1Service de Bactériologie-Virologie-Hygiène, Hôpital H. Mondor, Créteil, France.
The Journal of Antimicrobial Chemotherapy
|November 1, 1993
Summary
Cefepime demonstrates broad-spectrum antimicrobial activity against numerous Gram-positive and Gram-negative bacteria. This study evaluated its efficacy in vitro, highlighting its potential as a potent therapeutic agent.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Cefepime is a novel, broad-spectrum parenteral cephalosporin antibiotic.
- Understanding its in vitro activity against contemporary clinical isolates is crucial for guiding therapeutic use.
Purpose of the Study:
- To assess the in vitro antimicrobial activity of cefepime.
- To evaluate its efficacy against a diverse range of recent clinical isolates, including Gram-positive and Gram-negative bacteria.
Main Methods:
- In vitro susceptibility testing was performed.
- Minimum Inhibitory Concentrations (MICs) were determined for 1757 clinical isolates.
- Isolates included various Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus spp., Streptococcus spp., and others.
Main Results:
- Cefepime exhibited potent activity against non-cephalosporinase-producing Enterobacteriaceae (MIC50 ≤ 0.06 mg/L).
- Activity against Klebsiella pneumoniae varied, with higher MICs for extended-spectrum beta-lactamase producers.
- Effective concentrations were observed against Pseudomonas aeruginosa, Haemophilus spp., and Streptococci.
- Activity against methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci was variable, with higher MICs observed for resistant strains.
Conclusions:
- Cefepime displays significant in vitro activity against a wide array of clinically relevant bacteria.
- Its efficacy varies against specific resistant strains, necessitating careful consideration in treatment selection.
- Further clinical evaluation is warranted to confirm its therapeutic utility.