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New directions for breast cancer therapeutic research
1Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.
Abstract:
For the past two decades, attempts to improve chemotherapy for patients with breast cancer have emphasized the use of currently available agents. Research by drug discovery programs of the National Cancer Institute has identified a number of clinically promising novel agents. Conceivably, within the next several years there could be a doubling of the chemotherapy armamentarium for breast cancer--more than 30 active cytotoxic agents.
Insights
New breast cancer chemotherapy options are emerging. Research has identified promising novel agents, potentially doubling available treatments in the coming years.
Area of Science:
- Oncology
- Pharmacology
Background:
- For 20 years, breast cancer chemotherapy research focused on existing drugs.
- Limited progress in expanding chemotherapy options for breast cancer patients.
Purpose of the Study:
- To explore novel chemotherapy agents for breast cancer treatment.
- To identify promising new cytotoxic drugs beyond current therapies.
Main Methods:
- Review of drug discovery programs.
- Identification of clinically promising novel agents.
Main Results:
- National Cancer Institute research has identified several promising novel agents.
- Potential for a significant increase in available breast cancer chemotherapy drugs.
Conclusions:
- The chemotherapy armamentarium for breast cancer is expected to expand significantly.
- Over 30 active cytotoxic agents may become available for breast cancer treatment in the near future.