Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitation of desynchronosis

C M Winget, G H Bond, L S Rosenblatt

    Chronobiologia
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Early Root Response to Meloidogyne incognita in Resistant and Susceptible Alfalfa Cultivars.

    Journal of nematology·2009
    Same author

    Effects of Command and Control Vehicle (C2V) operational environment on soldier health and performance.

    Human performance in extreme environments : the journal of the Society for Human Performance in Extreme Environments·2003
    Same author

    Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.

    Neuroscience·2003
    Same author

    Characterization of the oligosaccharide structures associated with the cystic fibrosis transmembrane conductance regulator.

    Glycobiology·2000
    Same author

    Promethazine as a motion sickness treatment: impact on human performance and mood states.

    Aviation, space, and environmental medicine·2000
    Same author

    Light-emitting diodes and cool white fluorescent light similarly suppress pineal gland melatonin and maintain retinal function and morphology in the rat.

    Laboratory animal science·1999
    Same journal

    Models for chronobiologic risk and prepathology detection. A tribute to Bill W. Kennedy.

    Chronobiologia·1994
    Same journal

    Dora K. (Holly) Hayes.

    Chronobiologia·1994
    Same journal

    Agostino Carandente.

    Chronobiologia·1994
    Same journal

    In defense of proper cosinor analysis.

    Chronobiologia·1994
    Same journal

    "Cancer marker chronomes" assessed in the light of chronobioethics.

    Chronobiologia·1994
    Same journal

    Cardiovascular disease risk monitoring in the light of chronobioethics.

    Chronobiologia·1994
    See all related articles

    This study introduces a mathematical model to quantify circadian desynchronosis and recovery rates after time-zone changes. The model accurately predicts resynchronization times for physiological rhythms like body temperature in both monkeys and humans.

    Area of Science:

    • Chronobiology
    • Mathematical Modeling
    • Physiology

    Background:

    • Circadian desynchronosis, or jet lag, disrupts physiological systems after time-zone changes.
    • Understanding recovery rates is crucial for developing countermeasures.
    • Previous studies relied on flight data; ground-based simulations offer controlled environments.

    Purpose of the Study:

    • To develop and validate a mathematical model for quantifying desynchronosis.
    • To determine the rate of physiological recovery following simulated time-zone shifts.
    • To compare resynchronization rates across species and experimental conditions.

    Main Methods:

    • A mathematical model defining desynchronosis as a vector difference was developed.
    • The model was applied to ground-based photoperiod shift studies in monkeys.

    Related Experiment Videos

  • Body temperature and heart rate data were analyzed to estimate resynchronization times.

    • Main Results:

    • The model successfully described desynchronosis and resynchronization.
    • In monkeys, 95% recovery of body temperature rhythms after a 180-degree phase shift took 8.4 days.
    • Human studies showed similar resynchronization rates, with 95% recovery in 4.9 days for body temperature and heart rate.

    Conclusions:

    • The developed mathematical model provides a quantitative measure of desynchronosis and resynchronization.
    • Physiological rhythms exhibit predictable recovery rates after significant phase shifts.
    • Ground-based simulations effectively model circadian rhythm adjustments relevant to human time-zone travel.