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Thyroid function and attention-deficit hyperactivity disorder

J Elia1, C Gulotta, S R Rose

  • 1Department of Psychiatry, Medical College of Pennsylvania, Philadelphia.

Journal of the American Academy of Child and Adolescent Psychiatry
|February 1, 1994
PubMed
Summary
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Generalized resistance to thyroid hormone (GRTH) is rare in boys with attention-deficit hyperactivity disorder (ADHD). Routine thyroid function tests are not recommended for nonfamilial ADHD cases.

Area of Science:

  • Endocrinology
  • Neurodevelopmental Disorders

Background:

  • Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
  • Generalized resistance to thyroid hormone (GRTH) is a rare genetic condition affecting thyroid hormone action.

Purpose of the Study:

  • To investigate thyroid indices in boys with ADHD to identify potential evidence of GRTH.
  • To determine the prevalence of GRTH in a community-referred ADHD sample.

Main Methods:

  • Prospective collection of thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) values.
  • Study included 53 boys with ADHD and 41 age- and gender-matched controls.

Main Results:

  • No subjects exhibited thyroid hormone levels suggestive of global or pituitary GRTH.

Related Experiment Videos

  • Thyroid function tests did not reveal abnormalities indicative of GRTH in the ADHD cohort.
  • Conclusions:

    • Generalized resistance to thyroid hormone (GRTH) is an infrequent condition.
    • Routine thyroid function testing is not indicated for individuals with nonfamilial ADHD.