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Published on: March 23, 2014
Activity of sparfloxacin against Mycobacterium leprae measured by the proportional bactericidal test
R D McDermott-Lancaster1, D K Banerjee
1Department of Medical Microbiology, St. George's Hospital Medical School, London, U.K.
Abstract:
The activity of 25 mg/kg and 50 mg/kg sparfloxacin was measured against Mycobacterium leprae in normal (immunocompetent) mouse foot pads by the proportional bactericidal test. This was compared with the action of 25, 50, and 150 mg/kg ofloxacin by the same method. Sparfloxacin, at both concentrations, was found to be strongly bactericidal by this method, comparable to 150 mg/kg ofloxacin.
