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Updated: Aug 9, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Comparison of technetium-99m-Q3 and thallium-201 for detection of coronary artery disease in humans

M C Gerson1, J Lukes, E Deutsch

  • 1Department of Internal Medicine, University of Cincinnati, Ohio 45267-0542.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|April 1, 1994
PubMed

Insights

Technetium-99m-Q3 offers prompt myocardial visualization and comparable diagnostic accuracy to thallium-201 for detecting coronary artery disease. This new agent allows for a complete rest-exercise imaging sequence within 100 minutes.

Area of Science:

  • Nuclear Medicine
  • Cardiology
  • Radiopharmacology

Background:

  • Myocardial perfusion imaging is crucial for diagnosing coronary artery disease.
  • Thallium-201 (201Tl) has been the standard agent, but its imaging protocol can be lengthy.
  • Technetium-99m-Q3 (99mTc-Q3) is a novel myocardial imaging agent designed for rapid visualization.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of 99mTc-Q3 compared to 201Tl for detecting coronary artery disease.
  • To assess the feasibility of a rapid rest-exercise imaging protocol with 99mTc-Q3.

Main Methods:

  • Exercise and resting myocardial imaging were performed in 27 participants (19 with coronary artery disease, 2 without significant stenosis, 6 healthy volunteers).
  • Both 99mTc-Q3 and 201Tl were used for imaging in each participant.
  • The 99mTc-Q3 imaging sequence, including rest and exercise, was completed in under 100 minutes.

Main Results:

  • 99mTc-Q3 tomographic imaging demonstrated an overall accuracy of 89% for coronary disease detection, compared to 78% for 201Tl (p=ns).
  • Accuracy for detecting individual coronary stenoses was 83% for 99mTc-Q3 versus 75% for 201Tl (p=ns).
  • The rapid 99mTc-Q3 protocol was successfully completed within the specified timeframe.

Conclusions:

  • 99mTc-Q3 provides diagnostic accuracy comparable to 201Tl for both overall coronary disease detection and individual stenosis identification.
  • The rest-exercise imaging sequence with 99mTc-Q3 can be completed efficiently within 100 minutes.
  • 99mTc-Q3 represents a promising alternative myocardial imaging agent, offering similar diagnostic performance with a potentially shorter protocol.
Abstract

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