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Updated: Aug 13, 2026

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
Published on: October 8, 2013
Effect of inhaling heated vapor on symptoms of the common cold
G J Forstall1, M L Macknin, B R Yen-Lieberman
1Department of Infectious Disease, Cleveland Clinic Foundation, Ohio 44195.
Objective:
To test the efficacy of steam inhalation in treating common cold symptoms.
Design:
An in vitro study determined the temperature that inactivated rhinovirus: a temperature of 43 degrees C lasting at least 1 hour was needed. We then conducted a double-blind, placebo-controlled, randomized in vivo study.
Setting:
The virology laboratory and the outpatient department of the Cleveland (Ohio) Clinic Foundation.
Patients:
Sixty-eight Cleveland Clinic employee volunteers with symptoms of the common cold at the time of enrollment.
Intervention:
A single 60-minute treatment was given to the volunteers. The steam treatment group (n = 32) received 40 L/min of heated saturated air that raised the intranasal temperature to 43 degrees C. The placebo group (n = 36) received 2 L/min of ambient air at 20 degrees C to 24 degrees C.
Main Outcome Measures:
Subjective symptom scores for nasal congestion, nasal drainage, and sneezing and objective measures of nasal resistance were studied during a 7-day follow-up observation period.
Results:
There were no significant differences in daily symptom scores between the groups (P = .59 to .83). The only statistically significant differences between the groups were lower nasal resistances at baseline in the steam group (P = .04) and percent improvement in nasal resistance favoring the placebo group on day 7 (P = .01). However, these differences were of questionable clinical significance.
Conclusion:
We conclude that steam inhalation treatment had no beneficial effect on the cold symptoms of our volunteers.
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