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[The interrelation of serum lysozyme level and cytoplasmic lysozyme level]
1School of Allied Health Sciences, Yamaguchi University, Ube.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1994
Summary
Cytoplasmic and serum lysozyme levels are elevated in uremia and leukocytosis. Lysozyme staining aids in classifying leukemia types and predicting prognosis.
Area of Science:
- Hematology
- Immunology
- Biochemistry
Context:
- Leukocyte lysozyme, both cytoplasmic and serum, plays a role in various hematological conditions.
- Previous studies have not fully elucidated the relationship between cytoplasmic and serum lysozyme levels in different leukemic and non-leukemic disorders.
Purpose:
- To analyze and compare cytoplasmic and serum lysozyme levels in healthy individuals and patients with uremia, leukocytosis, leukemia, and myelodysplastic syndrome (MDS).
- To investigate the correlation between cytoplasmic and serum lysozyme levels and their utility in diagnosing and prognosing hematological malignancies.
Summary:
- Immunocytochemical analysis revealed significantly elevated cytoplasmic and serum lysozyme in uremia and leukocytosis compared to controls.
- Lysozyme staining intensity correlated with maturation in myelocytic and monocytic cells, with lymphocytes and early blast cells being negative.
- While some leukemias showed good correlation between cytoplasmic and serum lysozyme, others exhibited discrepancies, indicating serum levels do not fully reflect cytoplasmic levels.
Impact:
- Dual determination of cytoplasmic and serum lysozyme can aid in estimating leukemia types, cellular maturation, and total cell mass.
- This dual approach may offer a valuable tool for predicting prognosis in hematological disorders.