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Small intestinal microcirculatory effects of octreotide
W E Pofahl1, W A Arden, L D Beihn
1Department of Surgery, University of Kentucky Medical Center, Lexington 40536-0084.
The Journal of Surgical Research
|April 1, 1994
Summary
Octreotide acetate, a somatostatin analogue, unexpectedly increases jejunal microvascular blood flow. This effect is regulated at the microcirculatory level, not centrally or regionally.
Area of Science:
- Physiology
- Pharmacology
- Gastrointestinal Medicine
Background:
- Somatostatin and its analogue, octreotide acetate, are believed to reduce mesenteric blood flow.
- The precise level (central, regional, or microvascular) at which octreotide affects mesenteric circulation remains unclear.
Purpose of the Study:
- To investigate the hypothesis that the circulatory effects of octreotide are regulated at the microvascular level.
- To determine the impact of octreotide on superior mesenteric artery (SMA) flow and jejunal microcirculation.
Main Methods:
- Utilized perivascular ultrasonic flow probes to measure SMA flow in animals.
- Employed in vivo videomicroscopy to assess jejunal microcirculatory responses to octreotide.
- Administered octreotide intravenously and monitored hemodynamic and microcirculatory parameters.
Main Results:
- Octreotide infusion did not significantly alter systemic arterial pressure, cardiac index, or systemic vascular resistance index.
- Superior mesenteric artery (SMA) flow remained unchanged following octreotide administration.
- Jejunal first-order arteriole flow significantly increased (117.9% of baseline) due to enhanced red blood cell velocity, without changes in microvessel diameter.
Conclusions:
- Octreotide acetate enhances jejunal microvascular blood flow.
- The observed circulatory effects of octreotide are mediated at the microcirculatory level.
- This finding challenges the traditional understanding of octreotide's impact on mesenteric blood flow.