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Updated: Aug 11, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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Human cancer vaccines

J Sinkovics1, J Horvath, M Szabo-Szabari

  • 1Cancer Institute, St. Joseph's Hospital, Tampa, Florida 33607.

Leukemia
|April 1, 1994
PubMed

Immune T cells recognize peptide antigens presented to them within self-MHC molecules. Thus auto-tumor reactive lymphocyte populations can be generated. Antigenic expression can be modified and intensified and reactive lymphocyte populations can be expanded. Active immunization of the tumor-bearing human host can induce immune reactions of tumor rejection strength. Frequently, micrometastases can be eliminated and occasionally partial or complete remissions of gross metastases can be induced.

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