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Successful treatment of acute lymphoblastic leukemia in a child with cystic fibrosis
S Gururangan1, M Horner, J H Rodman
1Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
Medical and Pediatric Oncology
|January 1, 1994
Insights
A young girl with cystic fibrosis and acute lymphoblastic leukemia achieved complete remission. Her treatment involved high clearance rates of chemotherapy drugs, with adjusted doses for optimal exposure.
Area of Science:
- Pediatric Oncology
- Hematology
- Genetics
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
- Acute Lymphoblastic Leukemia (ALL) is a common childhood cancer.
- Co-occurrence of CF and ALL presents unique treatment challenges.
Observation:
- A 3.5-year-old female patient diagnosed with both CF and ALL.
- The patient received treatment for ALL while managing CF.
- Long-term follow-up was conducted post-treatment.
Findings:
- Successful treatment of ALL, achieving complete remission.
- Remission maintained for 36 months post-diagnosis.
- High clearance rates observed for three specific antineoplastic agents.
- Pharmacokinetic profiles indicated the need for dose adjustments.
Implications:
- Demonstrates feasibility of treating ALL in pediatric patients with CF.
- Highlights the importance of individualized drug dosing in complex cases.
- Suggests potential for novel therapeutic strategies in co-occurring conditions.
Abstract:
A 3 1/2 year old girl with cystic fibrosis who underwent successful treatment for acute lymphoblastic leukemia remains in complete remission 36 months after diagnosis. We also report high clearance rates of three antineoplastic agents in this patient. Drug doses were adjusted to achieve optimal systemic exposure.