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The use of subconjunctivally administered tissue plasminogen activator after trabeculectomy
1Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104.
Ophthalmic Surgery
|January 1, 1994
Abstract:
Blockage of aqueous flow in the early postoperative period can be devastating to the success of trabeculectomy. We used tissue plasminogen activator (tPA) subconjunctivally in an attempt to release a trabeculectomy flap that appeared to be adherent to its scleral bed. No change was noted 90 minutes after injection, but a highly elevated bleb was present on the first postoperative day. Subconjunctivally administered tPA may be useful in releasing the fibrin "glue" in cases with adherent trabeculectomy flaps.