Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed cerebral radiation necrosis

J G Morris1, P Grattan-Smith, P K Panegyres

  • 1Department of Neurology, Westmead Hospital, Australia.

The Quarterly Journal of Medicine
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RE: Do written consent forms provide medicolegal protection from litigation in radiotherapy?

Australasian radiology·2005
Same author

Delay in the clinical diagnosis of breast cancer: estimating its effect on prognosis, with particular reference to medical litigation.

Breast (Edinburgh, Scotland)·2004
Same author

Symptoms 2 weeks, 3 months and 12 months after treatment of early breast cancer: the patients' perspectives.

Breast (Edinburgh, Scotland)·2004
Same author

Breast cancer and malpractice litigation.

The Medical journal of Australia·1998
Same author

Structure of a muramic acid containing capsular polysaccharide from the pathogenic strain of Vibrio vulnificus ATCC 27562.

Carbohydrate research·1998
Same author

Colonization with vancomycin-resistant enterococci in chronic hemodialysis patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1998

Delayed cerebral radiation necrosis (DCRN) is a poorly recognized complication of cranial irradiation. This study details its distinct clinical picture and poor long-term outcomes in seven patients.

Area of Science:

  • Neurology
  • Radiation Oncology
  • Neuro-oncology

Background:

  • Cranial radiotherapy is used to treat various brain tumors.
  • Delayed cerebral radiation necrosis (DCRN) is a potential complication.
  • Understanding DCRN's clinical course is crucial for patient management.

Observation:

  • Seven patients with DCRN following radiotherapy for brain tumors were analyzed.
  • Neurological symptoms manifested with a mean latency of 22 months post-treatment.
  • Patients exhibited progressive dementia, somnolence, seizures, and stroke-like episodes.

Findings:

  • Imaging revealed progressive ventricular dilatation, cerebral atrophy, and white matter changes.
  • Long-term follow-up showed severe disability and mortality in most patients.

Related Experiment Videos

  • Diagnosis was often delayed, with only one patient diagnosed at initial presentation.

    • Implications:

    • DCRN presents a distinct but often unrecognized clinical syndrome.
    • Early recognition and diagnosis of DCRN are critical for improved patient outcomes.
    • Further research is needed to elucidate DCRN's pathogenesis and optimize treatment strategies.