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Secondary solid malignant tumors occurring after bone marrow transplantation for severe aplastic anemia given
J Y Pierga1, G Socie, E Gluckman
1Radiotherapy Department, Institut Gustave Roussy, Villejuif, France.
Abstract
Purpose:
We have evaluated irradiation doses received at location of secondary solid tumors occurring after bone marrow transplantation (BMT) in five of 147 patients grafted for severe aplastic anaemia.
Results:
All 5 tumors occurred within the radiation field penumbra. The estimated received dose varied from 6 Gy for one inner field secondary tumor, to 2.5 Gy for the remaining secondary tumors.
Conclusion:
Tumors may arise in the zone where the delivered radiation dose drops dramatically. Irradiation, with associated cofactors, may promote the development of epidermoid carcinoma in irradiated patients for BMT.