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Nifedipine in rat liver cirrhosis
C Cutrin1, J Menino, C Carballo
1Department of Medicine, Faculty of Medicine, University of Santiago de Compostela, Galicia, Spain.
Veterinary and Human Toxicology
|February 1, 1994
Abstract:
Rat liver cirrhosis induced by CCl4+ethanol was employed to assess the effectiveness of nifedipine in reducing liver injury. Nifedipine reduced the severity of hepatocellular necrosis, significantly decreased Mallory bodies (p < 0.01), decreased polymorphonuclear inflammatory infiltrate (p < 0.05) and reduced perivenular fibrosis. Plasma lactic acid levels were significantly increased in the CCl4+ethanol group (p < 0.01). Lactacidaemia remained at normal values when the calcium antagonist blocker was employed. Nifedipine did not significantly alter the incidence of cirrhosis in this experimental model.