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Related Experiment Videos

[Sympathetic ophthalmia in an elderly man]

T Matsubara1, M Uyama, J Kozaki

  • 1Department of Ophthalmology, Kansai Madical University, Osaka-fu, Japan.

Nippon Ganka Gakkai Zasshi
|March 1, 1994
PubMed
Summary
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Sympathetic ophthalmia developed in an elderly patient after a colon cancer treatment and eye injury. Prompt enucleation and corticosteroid therapy led to visual improvement, suggesting modified clinical presentation.

Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Background:

  • A 78-year-old male with metastatic colon cancer treated with 5-fluorouracil (5-FU) experienced a perforating eye injury.
  • The injured eye became phthisic, and two months later, the patient developed visual disturbances in the fellow eye.

Observation:

  • The patient presented with non-specific diffuse uveitis in the right eye, initially treated with systemic corticosteroids with worsening visual acuity.
  • A diagnosis of sympathetic ophthalmia was established based on the patient's history and ocular findings.

Findings:

  • Enucleation of the injured eye and continued corticosteroid treatment resulted in improvement of the right eye's vision.
  • Histopathology of the enucleated eye revealed granulomatous inflammation in the choroid.

Related Experiment Videos

  • HLA typing identified DR4, DR8, DR52, DR53, and DQ1.

    • Implications:

    • The case suggests that 5-FU treatment and advanced age may modify the clinical presentation of sympathetic ophthalmia.
    • This case highlights the importance of considering sympathetic ophthalmia in patients with a history of ocular trauma and uveitis, especially those undergoing chemotherapy.