[Effect of hyperthermic and isothermic mud application on hormonal function of normal and insufficient corpus luteum...

The aim of the paper has been to study the effect of a single procedure with hyper (42 degrees C) and isothermic (37 degrees C) mud exerted on the hormonal function of normal and insufficient corpus luteum in women. Procedure with mud was the first of its kind sanatorium treatment and consisted in simultaneous use of wrapping and vaginal pack. That was performed in the compartment from 18 to 22-nd day of menstrual cycle in 55 women with normal function of corpus luteum. The number included 32 with hyper, and 23 with isothermic mud. In a group of 41 studied women with insufficient corpus luteum, in 21 hyper and in 20 isothermic mud was used. In all the women prior to the procedure, 2 and 5 hours after the procedure, the accomplished radioimmunological determinations involved: concentration of FSH, LH, progesterone and estradiol in blood serum. Moreover, the level of adrenaline and noradrenaline in urine was established by fluorimetric method, calculated for gram of creatinine. In 10 of them concentration of FSH and LH was being determined every 15 minutes for the first 2 hours following the procedure. The employed procedure with hyper or isothermic mud in a similar manner led to transient increase in the concentration of progesterone and estradiol in blood sera of women with normal and insufficient hormonal function of corpus luteum. There was also a significant rise in excretion of adrenaline and noradrenaline in urine, particularly after hyperthermic mud application. The mentioned increase in the concentration of steroids was disconnected with the elevation affecting the concentration of gonadotropins, but likely due to their discharge from ovaries.