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Delayed allergic reaction to cefonicid

J A Martin1, M D Alonso, M Lázaro

  • 1Allergy Department, Hospital Ramon y Cajal, Madrid, Spain.

Annals of Allergy
|April 1, 1994
PubMed
Summary
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A delayed skin reaction occurred after cefonicid injection, a cephalosporin antibiotic. Patch testing confirmed cefonicid as the sole cause, distinguishing it from other beta-lactams.

Area of Science:

  • Pharmacology
  • Dermatology
  • Infectious Diseases

Background:

  • Intramuscular cefonicid, a second-generation cephalosporin, is used for bacterial infections.
  • Adverse drug reactions, including skin manifestations, are a concern with antibiotic therapy.

Observation:

  • A patient developed a delayed cutaneous reaction following intramuscular cefonicid administration.
  • Standard allergy testing revealed an isolated hypersensitivity to cefonicid.

Findings:

  • Skin testing showed a specific late-phase reaction exclusively to cefonicid.
  • Reactions to other beta-lactam antibiotics were negative, indicating cefonicid-specific sensitization.
  • Patch testing with 1% cefonicid yielded positive results at both 48 and 96 hours.

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Implications:

  • This case highlights the potential for delayed hypersensitivity reactions to cefonicid.
  • Distinguishing cefonicid allergy is crucial for patient safety and appropriate antibiotic selection.
  • Further investigation into cefonicid-specific immune mechanisms may be warranted.