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Related Experiment Videos

[Neuronal cell death and apoptosis]

Y Enokido1, H Hatanaka

  • 1Division of Protein Biosynthesis, Institute for Protein Research, Suita, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 1, 1994
PubMed
Summary

Programmed neuronal death, or apoptosis, is crucial for nervous system development and function. Understanding this process offers insights into neurodevelopment, neurodegenerative diseases, and brain aging.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Context:

  • Neuronal cell death is vital during nervous system development and in mature stages.
  • Physiological neuronal death occurs during development, particularly after axon targeting.
  • Apoptosis also plays a role in mature nervous system conditions like neurodegenerative diseases and aging.

Purpose:

  • To explore the mechanisms of programmed neuronal death (apoptosis) in the peripheral and central nervous systems.
  • To investigate the role of apoptosis in both neuronal development and neurodegeneration.
  • To understand how apoptosis contributes to the construction of neuronal networks and the aging process.

Summary:

  • Programmed neuronal death, mediated by apoptosis, is a key process in both developing and mature nervous systems.
  • Factors like neurotrophic agents and electrical input can prevent neuronal death, while inhibitors and DNA fragmentation are involved.
  • Apoptotic neuronal death is implicated in neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) and brain aging.

Impact:

  • Provides insights into the fundamental mechanisms of neuronal network construction during development.
  • Offers potential understanding of the causes behind neurodegenerative diseases and brain aging.
  • Highlights the significance of studying apoptosis for neurological health and disease research.

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