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[Hypertension and well-being: a study with indapamide]

T Rodrigues1, L Macieira, A Alfaiate

  • 1Instituto Nacional de Cardiologia Preventiva, Lisboa.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|January 1, 1994
PubMed
Summary

Indapamide effectively lowers blood pressure in patients with mild to moderate hypertension. This study also found significant improvements in patients' overall well-being and quality of life.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Arterial hypertension is a significant risk factor for cardiovascular diseases.
  • Effective management of hypertension is crucial for preventing long-term complications.

Purpose of the Study:

  • To evaluate the clinical efficacy of indapamide in patients with mild to moderate arterial hypertension.
  • To assess the impact of indapamide on patients' quality of life.

Main Methods:

  • An open prospective study was conducted with 32 patients diagnosed with mild to moderate hypertension.
  • Patients received a daily dose of 2.5 mg of indapamide for 12 weeks after placebo and wash-out periods.
  • Blood pressure and quality of life were monitored throughout the study.

Main Results:

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  • Indapamide significantly reduced both supine and standing systolic and diastolic blood pressures (p < 0.0001).
  • Patients reported an 80% improvement in quality of life, with notable benefits in asthenia, headache, attention, dizziness, tinnitus, and visual disturbances.
  • Biochemical parameters remained stable, with a slight, normal decrease in potassium levels.

Conclusions:

  • Indapamide demonstrates significant clinical efficacy in treating mild to moderate hypertension as monotherapy.
  • Indapamide positively impacts patients' quality of life, contributing to overall well-being.