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Related Experiment Videos

Selective radionuclide localisation in primary liver tumours (pilot study)

J R Novell1, A J Green, A J Hilson

  • 1University Dept of Surgery, Dept of Nuclear Medicine and Radiology, Clinical Oncology Unit, Royal Free Hospital, London, UK.

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
|January 1, 1994
PubMed
Summary

Radioactive iodine (131I-Lipiodol) shows promise for treating liver cancers. It delivers targeted internal radiation, with notable responses in hepatocellular carcinoma (HCC) patients, suggesting potential as a treatment of choice.

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Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • Cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) are primary liver cancers with limited treatment options.
  • Targeted radionuclide therapy offers a potential treatment modality for these malignancies.

Purpose of the Study:

  • To evaluate the therapeutic efficacy and safety of 131I-Lipiodol in patients with CCA and HCC.
  • To assess the biodistribution and radiation dosimetry of 131I-Lipiodol in these patient cohorts.

Main Methods:

  • A total of 8 CCA and 15 HCC patients received one or two doses of 131I-Lipiodol via hepatic arterial injection.
  • Tumor and organ radiation doses were calculated based on administered activity and retention.
  • Tumor response and patient survival were monitored.

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Main Results:

  • One CCA patient showed a complete response, while others experienced progression. Mean survival for CCA was 11.6 months.
  • HCC patients demonstrated high tumor-to-liver uptake ratios (up to 30:1).
  • Partial response (>50% tumor reduction) was observed in 40% of HCC patients, with a mean survival of 7.1 months.

Conclusions:

  • 131I-Lipiodol effectively delivers selective internal radiation to HCC foci.
  • It shows potential as a treatment of choice for HCC, especially in patients with cirrhosis and small tumors.
  • Further investigation is warranted for CCA treatment optimization.