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Infrared spectral analysis of extractables from poly(etherurethane urea) (PEUU) elastomers
M Renier1, J M Anderson, A Hiltner
1Department of Macromolecular Science, Case Western Reserve University, Cleveland, OH 44106.
Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
Summary
Biomedical Poly(etherurethane urea) (PEUU) elastomers showed minimal extraction (1-2 wt%) in vitro. Extractables included PEUU components and additives, Methacrol 2138 F and Santowhite powder.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Medical Device Materials
Background:
- Poly(etherurethane urea) (PEUU) elastomers are used in biomedical devices.
- These materials may be susceptible to leaching of components after implantation.
Purpose of the Study:
- To investigate the in vitro extractable components from PEUU elastomers.
- To quantify the amount of extractable material and identify its composition.
Main Methods:
- Four PEUU formulations with varying additives were subjected to an in vitro methanol extraction procedure.
- Fourier transform infrared spectroscopy (FT-IR) was used for qualitative and quantitative analysis of extractables.
Main Results:
- Only 1-2 wt% of the PEUU elastomers was extractable with methanol.
- Extractables comprised a PEUU component richer in soft segment than the bulk material.
- The additives Methacrol 2138 F (5 wt%) and Santowhite powder (1 wt%) were also identified in the extractables.
Conclusions:
- PEUU elastomers exhibit low extractability in vitro.
- The extraction process releases both PEUU oligomers and specific additives.
- Understanding extractable profiles is crucial for assessing the safety and performance of PEUU-based biomedical devices.