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[Antiphospholipid antibodies. Review]

M Diez-Ewald1

  • 1Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.

Investigacion Clinica
|January 1, 1993
PubMed
Summary

Antiphospholipid antibodies (APA) are immunoglobulins targeting phospholipids, linked to thrombosis and fetal loss. Diagnosis involves clotting tests and ELISA, with treatment ranging from observation to anticoagulation or immunosuppression.

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Area of Science:

  • Immunology
  • Hematology

Context:

  • Antiphospholipid antibodies (APA) are immunoglobulins targeting anionic phospholipids.
  • Initially termed "lupus anticoagulant," they are associated with systemic lupus erythematosus and other conditions.

Purpose:

  • To define antiphospholipid antibodies (APA), their associations, clinical manifestations, diagnostic methods, and therapeutic strategies.

Summary:

  • APA are IgG, IgM, or IgA antibodies against phospholipids, implicated in thrombosis, thrombocytopenia, and recurrent fetal losses.
  • Diagnosis relies on prolonged coagulation tests unresponsive to normal plasma and confirmed by ELISA.
  • Associated with diverse conditions, pregnancy, and even healthy individuals.

Impact:

  • Understanding APA is crucial for diagnosing and managing thrombotic and obstetric complications.
  • Treatment strategies vary from watchful waiting to anticoagulant or immunosuppressive therapies, including immunoglobulin and plasmapheresis.

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