Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet selenium as indicator of wheat selenium intake

K Bibow1, H M Meltzer, H H Mundal

  • 1Department of Chemistry, University of Oslo, Norway.

Journal of Trace Elements and Electrolytes in Health and Disease
|September 1, 1993
PubMed
Summary

Increased wheat selenium intake boosted platelet, serum, and whole-blood selenium levels in women over six weeks. Glutathione peroxidase (GSH-Px) levels remained unchanged, indicating specific tissue responses to selenium supplementation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invited review: Turning dairy food waste into valuable products via yeast bioproduction.

Journal of dairy science·2026
Same author

The prognostic significance of stress-phenotyping for stroke incidence: the Malmö Diet and Cancer Study.

Stress (Amsterdam, Netherlands)·2024
Same author

Identifying the suite of genes central to swimming in the biocontrol bacterium <i>Pseudomonas protegens</i> Pf-5.

Microbial genomics·2024
Same author

The impact of prediabetes and diabetes on endothelial function in a large population-based cohort.

Blood pressure·2024
Same author

The impact of age on endothelial dysfunction measured by peripheral arterial tonometry in a healthy population-based cohort - the Malmö offspring study.

Blood pressure·2023
Same author

Ventricular-arterial coupling (VAC) in a population-based cohort of middle-aged individuals: The STANISLAS cohort.

Atherosclerosis·2023

Area of Science:

  • Human Nutrition
  • Biochemistry
  • Trace Elements

Background:

  • Selenium (Se) is an essential trace element crucial for various physiological functions.
  • Dietary selenium intake varies based on geographical location and food sources.
  • Understanding selenium bioavailability from different food matrices is important for nutritional guidance.

Purpose of the Study:

  • To investigate the impact of increased wheat-derived selenium intake on selenium levels in blood components and glutathione peroxidase (GSH-Px) activity.
  • To assess the relationship between dietary selenium intake and selenium concentrations in platelets, serum, and whole blood.
  • To determine if platelet selenium levels correlate with overall selenium intake.

Main Methods:

  • A six-week dietary intervention study involving 14 healthy Norwegian females.

Related Experiment Videos

  • Participants consumed 60 micrograms of selenium per day from wheat selenium.
  • Measurements included selenium concentrations in platelets, serum, whole blood, and GSH-Px activity before and after the intervention.

    • Main Results:

    • Significant increases were observed in platelet selenium (9.1 to 11.4 mumol/L), serum selenium (1.43 to 1.63 mumol/L), and whole-blood selenium (1.77 to 2.01 mumol/L).
    • The percentage increase in platelet selenium was double that of serum and whole blood.
    • Glutathione peroxidase (GSH-Px) levels showed no significant alteration during the study period.
    • Platelet selenium initially showed no significant correlation with intake, but reflected total intake by the study's end, albeit non-linearly.

    Conclusions:

    • Wheat-derived selenium supplementation effectively increases selenium levels in human blood compartments, particularly in platelets.
    • Platelet selenium appears to be a sensitive indicator of recent selenium intake, though not in a simple linear fashion.
    • Glutathione peroxidase activity was not significantly affected by the moderate increase in selenium intake over six weeks in this cohort.