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Platelet function disorders in north India

A K Saraya1, R Saxena, P S Dhot

  • 1All India Institute of Medical Sciences, Ansari Nagar, New Delhi.

The National Medical Journal of India
|January 1, 1994
PubMed
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Platelet function disorders in North India show similar patterns to Western countries, with a higher incidence of thrombopathic thrombasthenias. This study details the types and frequencies of these bleeding disorders in Indian patients.

Area of Science:

  • Hematology
  • Clinical Medicine
  • Genetics

Background:

  • Platelet function disorders are common causes of bleeding.
  • Existing data on the incidence and types of these disorders in India are limited.

Purpose of the Study:

  • To investigate the clinical and laboratory features of platelet function disorders in North Indian patients.
  • To compare the incidence of various platelet function disorders in India with Western populations.

Main Methods:

  • A retrospective study of 144 North Indian patients with bleeding diathesis was conducted between 1970 and 1991.
  • Patients with coagulation disorders, von Willebrand's disease, or a history of drug ingestion were excluded.

Main Results:

  • Isolated platelet factor 3 availability defect was the most common (56 cases), followed by thrombasthenias (49 cases).

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  • Thrombopathic thrombasthenias, characterized by impaired platelet aggregation and reduced platelet factor 3, were more frequent in India than in Western countries.
  • Classical Glanzmann's thrombasthenia and thrombopathic thrombasthenia with absent platelet aggregation were associated with severe bleeding and suggested autosomal recessive inheritance.

    • Conclusions:

    • The spectrum of platelet function disorders in India resembles that of Western populations.
    • A notable difference is the higher incidence of thrombopathic thrombasthenias observed in the Indian cohort.