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Long survival in patients with acquired immune deficiency syndrome-related primary central nervous system lymphoma
1University of California, Department of Neurosciences, San Diego 92103.
Background:
Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI).
Methods:
Four (of approximately 40) patients with AIDS and PCNSL seen by the University of California, San Diego (UCSD) Neuro-Oncology service were treated with multimodal therapy, including WBI with hydroxyurea, followed by 3 cycles of procarbazine/lomustine/vincristine (PCV) chemotherapy.
Results:
Survival after tumor diagnosis ranged from 11 to 16 months, with a median of 13.5 months.
Conclusion:
Selected patients with AIDS and PCNSL may have long survival when treated with multimodal therapy.