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[A new insulin-sensitivity index for the population-based study]

G W Li1, X R Pan

  • 1Endocrinology Department, China-Japan Friendship Hospital, Beijing.

Zhonghua Nei Ke Za Zhi
|October 1, 1993
PubMed
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A new simple insulin sensitivity index, calculated from fasting glucose and insulin, strongly correlates with established clamp methods. This validated index accurately assesses insulin sensitivity in diverse populations, including Chinese individuals.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Clinical Diagnostics

Background:

  • Insulin resistance is a key factor in metabolic disorders.
  • Accurate assessment of insulin sensitivity is crucial for diagnosis and management.
  • Current methods like the euglycemic insulin clamp are complex and time-consuming.

Purpose of the Study:

  • To introduce and validate a novel, simple index for measuring insulin sensitivity.
  • To assess the correlation of this new index with the gold standard euglycemic insulin clamp.
  • To evaluate the applicability of the new index in the Chinese population.

Main Methods:

  • A new index was developed: the reciprocal of the product of fasting plasma glucose and insulin.
  • The new index was correlated with the M value (insulin-mediated glucose disposal rate) from euglycemic insulin clamp studies.

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  • Validation was performed in 320 American subjects (two races) and 874 Chinese subjects.

    • Main Results:

    • The new index showed a significant positive correlation (r > 0.7, P = 0.0001) with the M value in American subjects.
    • Insulin sensitivity values derived from the new index in Chinese subjects closely mirrored those obtained by clamp methods in American populations.
    • Specific IS values were reported for normal glucose tolerance, impaired glucose tolerance, and diabetic states across ethnic groups.

    Conclusions:

    • The novel, simple insulin sensitivity index is a reliable and practical tool for assessing insulin sensitivity.
    • The index demonstrates strong correlation with the euglycemic insulin clamp method.
    • This new index is suitable for evaluating insulin sensitivity in the Chinese population and potentially other diverse groups.