Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible valproate-induced extrapyramidal disorders

E Sasso1, S Delsoldato, A Negrotti

  • 1Institute of Neurology, University of Parma, Italy.

Epilepsia
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus.

Cancer gene therapy·2024
Same author

Impact of epilepsy after severe brain injury on safe resumption of driving: two-year follow-up.

Functional neurology·2018
Same author

Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center?

Neuro-oncology practice·2015
Same author

Adalimumab improves joint-related and skin-related functional impairment in patients with psoriatic arthritis: patient-reported outcomes of the Adalimumab Effectiveness in Psoriatic Arthritis Trial.

Annals of the rheumatic diseases·2006
Same author

REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2005
Same author

Effects of disease progression and L-dopa therapy on the control of reaching-grasping in Parkinson's disease.

Neuropsychologia·2005
Same journal

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video-electroencephalographic study.

Epilepsia·2026
Same journal

Perineuronal net abnormalities in epileptic human tissue.

Epilepsia·2026
Same journal

Cortical stimulation reveals effective disconnection of the epileptogenic network at seizure onset.

Epilepsia·2026
Same journal

Anterior cingulate cortex neuron subtypes differentially regulate seizures.

Epilepsia·2026
Same journal

Ultrafast oscillations in the human brain and their functional significance.

Epilepsia·2026
Same journal

Magnetoencephalographic source imaging improves localization of the epileptogenic zone in multimodal imaging evaluation.

Epilepsia·2026
See all related articles

Transient parkinsonism occurred in two young epilepsy patients treated with valproate (VPA). Symptoms resolved spontaneously within weeks, suggesting a reversible side effect of VPA therapy.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Epilepsy treatment often involves valproate (VPA), a broad-spectrum anticonvulsant.
  • Extrapyramidal symptoms are rare but recognized adverse effects of certain medications.

Observation:

  • Two young patients with epilepsy developed transient parkinsonism during valproate therapy.
  • The parkinsonian symptoms included bradykinesia and bradyphrenia.

Findings:

  • The extrapyramidal disorder resolved spontaneously within weeks without intervention.
  • Susceptibility did not appear related to patient age or VPA dosage.
  • Rapid recovery and specific negative signs characterized this reaction.

Implications:

  • Valproate may induce a rare, reversible parkinsonian syndrome.

Related Experiment Videos

  • The underlying pathophysiology may involve transient GABA pathway imbalances affecting dopamine.
  • Further research is needed to elucidate the exact mechanisms of this toxic reaction.