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Hypothalamic growth hormone deficiency in a patient with ring chromosome 18
A Meloni1, L Boccone, L Angius
1Istituto di Clinica e Biologia dell'età Evolutiva, Università degli Studi di Cagliari, Italy.
European Journal of Pediatrics
|February 1, 1994
Abstract:
We report on a boy with a ring 18 chromosome associated with hypothalamic growth hormone (GH) deficiency. A 12-month trial of GH replacement therapy (0.5 U/kg/week) resulted in a marked growth acceleration. Our findings emphasise the need of evaluating GH secretion in patients with abnormalities of the 18 chromosome.