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Updated: Aug 17, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
Elevated serum thyrotropin [TSH] levels in critically ill patients with acquired immunodeficiency syndrome (AIDS)
Study Objective:
To determine thyrotropin (TSH) reserve in critically ill patients with Acquired Immunodeficiency Syndrome (AIDS).
Design:
Prospective longitudinal.
Setting:
Six hundred (600) bed municipal hospital serving a poor neighborhood in New York City with a high incidence of AIDS mainly from intravenous drug abuse.
Patients And Methods:
Twelve (12) patients with AIDS, who were in the Intensive Care Unit or critically ill on medical wards, were evaluated consecutively with baseline thyroid function tests and serum thyrotropin (TSH) response to thyroid releasing hormone testing.
Results:
66.7% of patients had elevated TSH levels. All patients had low triiodothyronine (T3), six patients had low thyroxine (T4) levels.
Results:
(cont'd). Six patients met the criteria for hypothyroidism. Two patients met the criteria for subclinical hypothyroidism.
Conclusion:
Elevated TSH levels and hypothyroidism are common in our critically ill population with AIDS.
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